Postdoctoral Researcher

UHN is Canada's No. 1 hospital and the world's No. 1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members. UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN's vision is to build A Healthier World and its only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Union: Non-Union
Site: Princess Margaret Cancer Research Tower
Department: Research
Reports to: Dr. Robert Vanner, Principal Investigator
Work Model: On-Site
Grade: VE:01
Hours: 37.5 hours per week
Salary: $53,303 - $63,963 Annually (To commensurate with experience and consistent with UHN compensation policy)
Shifts: Day
Status: Temporary Full-time
Closing Date: March 1, 2024

Position Summary
We are recruiting a curious and driven Postdoctoral Researcher to join our group on a funded project investigating mechanisms of clonal hematopoiesis-accelerated oncogenesis and implementing innovative preventative strategies. We are based at the Princess Margaret Cancer Centre in Toronto, Canada, with full support from state-of-the-art facilities across Toronto's Discovery District. We study population cohorts, primary patient samples with single-cell technologies, and pre-clinical animal models to define and target clonal hematopoiesis-induced pathology.

Duties

• Plan and carry out experiments: design and execute laboratory experiments using techniques in molecular and cell biology to investigate clonal hematopoiesis as a driver of cancer formation and novel targetable axis for early intervention.
• Data Analysis and Interpretation: Undertake comprehensive bioinformatic and statistical analyses to interpret experiments and draw meaningful conclusions from results.
• Cell isolation: isolate and characterize cell populations from hematopoietic and tumor tissues using flow cytometry and cell sorting for analysis in functional assays.
• Collaboration and Teamwork: Closely collaborate with other researchers including post-doctoral fellows, technicians, and students to maintain a positive, supportive research environment
• Literature Review and Scientific Development: Keep up to date on research advancements in clonal hematopoiesis and somatic mosaicism to identify new research opportunities and propose novel hypotheses.
• Writing: Prepare manuscripts for peer-reviewed journals and contribute to grant applications that secure additional funding for research projects.
• Scientific mentorship: mentor and direct junior trainees including graduate or undergraduate students on designing, performing, and analyzing experiments.
• Presentations: Regularly present research findings at lab meetings, local seminars, national/international conferences to share progress and obtain feedback.

• PhD must be obtained within the previous 5 years, or an MD obtained within the previous 10 years
• Expertise in molecular biology and experience with computational biology/data analysis
• Excellent analytical and problem-solving skills
• Proven track record of scientific publications
• Experience in flow cytometry or working with animals is an asset.
• A background in cancer biology, genetics, hematopoiesis, or immunology is valued

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.